Jeffrey M. Gross

Maskless and on-chip LED-array microscope with spatially-varying angle calibration for centimeter-scale phase imaging

This paper presents a computational framework for mask-free on-chip phase imaging with adaptive calibration of spatially-varying illumination angles, achieving centimeter-scale imaging with micron-level resolution.

Zebrafish optic nerve injury results in systemic retinal ganglion cell dedifferentiation

This study shows that zebrafish retinal ganglion cells dedifferentiate after optic nerve injury, resembling immature RGCs, and identifies potential therapeutic targets for human RGC protection.

tet2 and tet3 regulate cell fate specification and differentiation events during retinal development

The paper investigates the role of Tet2 and Tet3 in retinal development using scRNA-seq, identifying defects in cell fate specification and differentiation.

Interleukin-34 and debris clearance by mononuclear phagocytes drive retinal pigment epithelium regeneration in zebrafish

This study identifies interleukin-34 signaling and mononuclear phagocyte debris clearance as critical for RPE regeneration in zebrafish.

A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium

The paper presents a CRISPR-Cas9-mediated F0 screen in zebrafish to identify genes regulating RPE regeneration, finding eight positive and seven negative regulators, including cldn7b with novel roles in macrophage infiltration and debris clearance.

mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish

This study shows that mTOR activity is necessary and sufficient for RPE regeneration in zebrafish, with immune cell interactions playing a key role in this process.

Retinal ganglion cell survival after severe optic nerve injury is modulated by crosstalk between JAK/STAT signaling and innate immune responses in the zebrafish retina

dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye

This study shows that dnmt1 is essential for maintaining retinal stem cells in the zebrafish ciliary marginal zone by regulating proliferation, gene expression, and repression of retroelements.

Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure

The paper shows that Mitf-family transcription factors are required in cranial neural crest cells to promote choroid fissure closure and that their absence causes colobomas.

Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation

This study demonstrates that zebrafish can regenerate a functional RPE monolayer after widespread RPE ablation, with regeneration originating from peripheral RPE cells and requiring Wnt signaling.