Lilian R. Heil

Revisiting resonance-excitation collision-induced dissociation for data-independent acquisition

This study revisits resonance-excitation collision-induced dissociation (reCID) for DIA proteomics, showing it can achieve performance comparable to HCD with optimized settings and libraries.

Low-resolution FAIMS for increased peptide coverage in low-load and single-cell proteomics

This paper shows that lowering FAIMS resolution improves peptide identification in low-load and single-cell proteomics by increasing ion transmission and sensitivity.

Development of highly multiplex targeted proteomics assays in biofluids using the Stellar mass spectrometer

The paper develops scalable targeted proteomics assays using the Stellar mass spectrometer for analyzing biofluids, demonstrating high sensitivity and multiplexing capabilities.

Comet fragment-ion indexing for enhanced peptide sequencing

This paper enhances the Comet search engine with fragment-ion indexing, improving peptide spectral matching speeds by up to 94% while maintaining accuracy in proteomics applications.

A workflow for targeted proteomics assay development using a versatile linear ion trap

The paper develops a workflow for targeted proteomics using a hybrid quadrupole-linear ion trap instrument, demonstrating consistent quantification without high-mass accuracy.

Hybrid Quadrupole Mass Filter Radial Ejection Linear Ion Trap and Intelligent Data Acquisition Enable Highly Multiplex Targeted Proteomics

The paper introduces a new MS platform with enhanced acquisition rates and real-time chromatogram alignment, enabling high multiplex targeted proteomics with improved sensitivity and throughput.

Dynamic Data Independent Acquisition Mass Spectrometry with Real-Time Retrospective Alignment

This paper introduces a dynamic DIA mass spectrometry method that improves quantitative sensitivity by adjusting MS/MS windows during chromatographic separation.

Spontaneous Isomerization of Asp387 in Tau is Diagnostic for Alzheimer's Disease: An Endogenous Indicator of Reduced Autophagic Flux

The paper identifies isomerization of Asp387 in tau as a marker of reduced autophagic flux in Alzheimer's disease using mass spectrometry analysis of brain tissue.

A flexible workflow for building spectral libraries from narrow window data independent acquisition mass spectrometry data

This paper introduces a workflow to build spectral libraries from DIA mass spectrometry data, showing it can detect phosphorylated peptides and outperforms library-free methods in accuracy and sensitivity.