PARP10 condensation inhibits viral infection via targeting NAD+ homeostasis
Xiaoxin Chen, Qi Keng Xu, Yi Liu, Zhenshuo Zhu, Ziqiu Wang, Yun Zhang, Qi Chen, Le Tian, Zhiying Yao, Zhubing Shi, Peiguo Yang
This study identifies PARP10 condensation as an antiviral mechanism that disrupts NAD+ homeostasis to inhibit viral replication.
bioRxiv · Dec 25, 2025 · PreprintCell Biology