Author

Le Tian

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Peiguo YangiD· 2 shared Qi CheniD· 2 shared Yi LiuiD· 2 shared Yun ZhangiD· 2 shared Zhenshuo ZhuiD· 2 shared Zhiying Yao· 2 shared Ziqiu WangiD· 2 shared Hong Joo KimiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Peiguo YangORCID

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2 papers

Recent·Most cited

Alphaviral nonstructural protein-host RBP co-condensation as a mechanism to sustain virus replication

Yi Liu, Zhiying Yao, Yun Zhang, Zhenshuo Zhu, Ziqiu Wang, Qi Chen, Zemin Yang, Yexuan He, Xiaoxin Chen, Le Tian, Jiang Du, Jinjun Wu, Hong Joo Kim, Jing Huang, Yongdeng Zhang, , Peiguo Yang

This study identifies nsP3-RBP co-condensation as a mechanism alphaviruses use to sustain replication, showing disruption of these condensates can inhibit viral replication.

Molecular Cell · May 21, 2026Peer-reviewedCell Biology

PARP10 condensation inhibits viral infection via targeting NAD+ homeostasis

Xiaoxin Chen, Qi Keng Xu, Yi Liu, Zhenshuo Zhu, Ziqiu Wang, Yun Zhang, Qi Chen, Le Tian, Zhiying Yao, Zhubing Shi, Peiguo Yang

This study identifies PARP10 condensation as an antiviral mechanism that disrupts NAD+ homeostasis to inhibit viral replication.

bioRxiv · Dec 25, 2025 · PreprintCell Biology