Ziqiu Wang

Alphaviral nonstructural protein-host RBP co-condensation as a mechanism to sustain virus replication

This study identifies nsP3-RBP co-condensation as a mechanism alphaviruses use to sustain replication, showing disruption of these condensates can inhibit viral replication.

Alphaviral capsid proteins inhibit stress granule assembly via competitive RNA binding with G3BP1

This study identifies how alphavirus capsid proteins inhibit stress granule assembly by competing with G3BP1 for RNA binding, revealing a conserved mechanism across alphaviruses.

PARP10 condensation inhibits viral infection via targeting NAD+ homeostasis

This study identifies PARP10 condensation as an antiviral mechanism that disrupts NAD+ homeostasis to inhibit viral replication.

A multivalent mRNA-LNP therapeutic vaccine with broad cross-genotype immunogenicity elicits clearance of HBV infected hepatocytes

This paper develops an mRNA-LNP vaccine, mRNA-1965, that clears HBV-infected hepatocytes in mice by inducing broad immune responses across HBV genotypes.

mRNA-1273.251 and mRNA-1283.251 vaccines expressing SARS-CoV-2 variant LP.8.1 antigens broadly neutralize contemporary JN.1-lineage viruses

This study develops and evaluates two mRNA vaccines targeting the LP.8.1 variant of SARS-CoV-2, showing broad neutralization against JN.1-lineage subvariants.