PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer
Fan Liu, Weixiao Liu, Yawen Tan, Yaxin Shang, Sihui Ling, Xiaokun Jiang, Zhen Zhang, Shiyao Sun, Ping Xie
This study shows that PTEN neddylation promotes resistance to CDK4/6 inhibitors in breast cancer by activating the PI3K/Akt pathway and AP-1 transcription factor, and identifies Echinacoside as a potential inhibitor.
Oncogene · Jun 18, 2025Peer-reviewedCancer Biology