A phenotypic rescue approach identifies lineage regionalization defects in a mouse model of DiGeorge syndrome.
Gabriella Lania, Monica Franzese, Noritaka Adachi, Marchesa Bilio, Gemma Flore, Annalaura Russo, Erika D’Agostino, Claudia Angelini, Robert G. Kelly, Antonio Baldini
The paper identifies lineage regionalization defects in a mouse model of DiGeorge syndrome using vitamin B12 treatment and shows that SLUG+ cells are mislocalized and partially rescued by treatment.
Disease Models & Mechanisms · Aug 10, 2022Peer-reviewedDevelopmental Biology