Summer B. Thyme

The paper develops a computational method to prioritize neuroactive ligands using structural data and zebrafish testing, identifying effective antagonists for hypocretin receptors.

This study links the schizophrenia risk gene znf804a to circadian behaviors in zebrafish by showing altered gene expression and transcript processing in mutants.

StrIPETrack is a Python-based tracking software for zebrafish behavior that supports flexible ROI definitions and complex assays, providing accurate and detailed behavioral phenotyping.

The paper identifies dysregulation of cholesterol metabolism as a shared molecular consequence of schizophrenia risk mutations in zebrafish models.

This study inhibits hedgehog signaling in zebrafish embryos by overexpressing Gli3R and identifies transcriptomic changes affecting multiple cell types and ionocyte development.

This study removes 45 microexons in zebrafish using CRISPR/Cas9 and finds minimal developmental impact on brain morphology and function, with some exceptions in specific microexons.

The study investigates neurodevelopmental effects of a zebrafish Gal4 transgenic line, finding phenotypes linked to transgene insertion site rather than Gal4 toxicity.

The paper identifies cell type-specific regulatory elements in nine mammals and shows their conservation and association with neuropsychiatric and neurodegenerative disease risks.

This study identifies diencephalic and neuropeptidergic dysfunction in zebrafish with autism-risk mutations, revealing potential molecular and behavioral mechanisms.

This study characterizes a zebrafish ebf3a mutant, revealing brain size reduction, functional impairments, and gene expression changes in sensory systems and the cerebellum.

This study shows that both mosaic and non-mosaic pcdh19 mutations in zebrafish lead to neuronal hyperexcitability, challenging the idea that mosaicism alone causes PCDH19-related epilepsy.

The paper describes a low-cost, modular system for high-throughput zebrafish behavior phenotyping, validated with mutant analysis and best practices for larval growth.

The paper mutates zebrafish orthologues of schizophrenia-associated genes to identify phenotypic candidates and shared functions.