CTCF is a Barrier for Totipotent-like Reprogramming
Teresa Olbrich, María Vega-Sendino, Desiree Tillo, Wei Wu, Nicholas Zolnerowich, Andy D. Tran, Catherine Nicole Domingo, Mariajose Franco, Marta Markiewicz-Potoczny, Gianluca Pegoraro, Peter C FitzGerald, Michael J. Kruhlak, Eros Lazzerini Denchi, Elphège Pierre Nora, André Nussenzweig, Sergio Ruiz
This study identifies CTCF as a barrier to 2C-like reprogramming in ESCs, showing its role in maintaining chromatin structure and that its depletion promotes totipotent-like state conversion.
bioRxiv · Dec 20, 2020 · PreprintDevelopmental Biology