Author

Sergio Ruiz

National Institutes of HealthORCID 0000-0002-0177-6965Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:bulk RNA-seq· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:DNA methylation· 1

Frequent Co-Authors

Andy D. TraniD· 3 shared Catherine Nicole Domingo· 3 shared Desiree TilloiD· 3 shared María Vega-SendinoiD· 3 shared Michael J. KruhlakiD· 3 shared Teresa Olbrich· 3 shared Bechara SaykaliiD· 2 shared Peter C FitzGeraldiD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersDevelopmental Biology

Andy D. TranORCID

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4 papers

Recent·Most cited

Lineage-specific CDK activity dynamics characterize early mammalian development

Bechara Saykali, Andy D. Tran, James A. Cornwell, Matthew A. Caldwell, Paniz Rezvan Sangsari, Nicole Y. Morgan, Michael J. Kruhlak, Steven D. Cappell, Sergio Ruiz

The paper quantifies CDK activity in mouse embryos and shows it decreases in trophectoderm cells before implantation, correlating with FGF4 signaling, but does not determine cell fate.

Cell Reports · Apr 1, 2025Peer-reviewedDevelopmental Biology

The homeobox transcription factor DUXBL controls exit from totipotency

María Vega-Sendino, Felipe F. Lüttmann, Teresa Olbrich, Yanpu Chen, Carsten Tobias Kuenne, Paula Stein, Desiree Tillo, Grace I. Carey, Jiasheng Zhong, Virginia Savy, Lenka Radonova, Tianlin Lu, Bechara Saykali, Kee-Pyo Kim, Catherine Nicole Domingo, , Sergio Ruiz

This study identifies DUXBL as a key factor promoting the silencing of the 2C transcriptional program during exit from totipotency.

Nature Genetics · Mar 20, 2024Peer-reviewedDevelopmental Biology

The ETS Transcription Factor ERF controls the exit from the naive pluripotent state

María Vega-Sendino, Teresa Olbrich, Desiree Tillo, Andy D. Tran, Catherine Nicole Domingo, Maurício Machaim Franco, Peter C FitzGerald, Michael J. Kruhlak, Sergio Ruiz

This study identifies ERF as a key transcription factor that facilitates the exit from naive pluripotency by regulating enhancer activity and DNMT3B expression during the transition to primed pluripotency.

bioRxiv · Feb 1, 2021 · PreprintDevelopmental Biology

CTCF is a Barrier for Totipotent-like Reprogramming

Teresa Olbrich, María Vega-Sendino, Desiree Tillo, Wei Wu, Nicholas Zolnerowich, Andy D. Tran, Catherine Nicole Domingo, Mariajose Franco, Marta Markiewicz-Potoczny, Gianluca Pegoraro, Peter C FitzGerald, Michael J. Kruhlak, Eros Lazzerini Denchi, Elphège Pierre Nora, André Nussenzweig, Sergio Ruiz

This study identifies CTCF as a barrier to 2C-like reprogramming in ESCs, showing its role in maintaining chromatin structure and that its depletion promotes totipotent-like state conversion.

bioRxiv · Dec 20, 2020 · PreprintDevelopmental Biology