Author

Anaïs Brassier

Hôpital Necker-Enfants MaladesORCID 0000-0002-9528-3546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christine Jenny· 2 shared Jérémie CosetteiD· 2 shared Julie Oustelandt· 2 shared Marine LaurentiD· 2 shared Mario AmendolaiD· 2 shared Rim Harb· 2 shared Aristide Ferrante· 1 shared Cláudia PiccoliiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Christine Jenny

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Rescue of lysosomal acid lipase deficiency in mice by rAAV8 liver gene transfer.

Marine Laurent, Rim Harb, Christine Jenny, Julie Oustelandt, Simon Jimenez, Jérémie Cosette, Francesca Landini, Aristide Ferrante, Guillaume Corre, Nemanja Vujić, Cláudia Piccoli, Anaïs Brassier, Laetitia van Wittenberghe, Giuseppe Ronzitti, Dagmar Kratky, , Mario Amendola

The paper develops a liver-targeted gene therapy using recombinant AAV8 to cure Lysosomal acid lipase deficiency by correcting lipid accumulation and normalizing gene expression and mitochondrial function in a mouse model.

Communications Medicine · Apr 11, 2025Peer-reviewedMolecular Biology

Novel cytometry-based characterization of lysosomal storage disease affected patient's cells

Marine Laurent, Jérémie Cosette, Giulia Pavani, Sarah BAYOL, Christine Jenny, Rim Harb, Julie Oustelandt, Anaïs Brassier, Daniel Stockholm, Mario Amendola

This paper characterizes lysosomal storage disease using imaging and cytometry to assess lipid homeostasis in patient cells and validates findings in alternative models.

bioRxiv · Mar 18, 2025 · PreprintPathology