Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephalic cortical malformation
Indra Niehaus, Michaela Wilsch‐Bräuninger, Felipe Mora‐Bermúdez, Fabian Rost, Mihaela Bobić‐Rasonja, Velena Radošević, Marija Milković Periša, Pauline Wimberger, Mariasavina Severino, Alexandra Haase, Ulrich Martin, Karolina Künzel, Kaomei Guan, Katrin Neumann, Noreen Walker, , Michael Heide
The paper uses cerebral organoids from patients with actin mutations to show that altered cleavage plane orientation in ventricular zone progenitors leads to microcephaly.
EMBO Reports · Dec 10, 2025Peer-reviewedNeuroscience