Michaela Wilsch‐Bräuninger

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

This study identifies HNF1B and NPHP3 mutations as causes of a new pancreatic disease, ciliogenic pancreatopathy, characterized by acinar atrophy and adipose replacement, and links ciliary dysfunction to pancreatic dysfunction in humans and mice.

Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephalic cortical malformation

The paper uses cerebral organoids from patients with actin mutations to show that altered cleavage plane orientation in ventricular zone progenitors leads to microcephaly.

Species-specific basal fluidization shapes early forebrain development

This study identifies basal fluidization in human neuroepithelia as a tissue-level mechanism driving forebrain expansion, distinct from other great apes and mice.

Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc

This study investigates how the apical extracellular matrix (aECM) regulates fold morphogenesis in the Drosophila wing disc, showing its role in stabilizing tissue folding and shaping the adult wing.

The Role of Purine Interactions in Biogenic Crystal Shape Determination

This paper investigates how purine interactions regulate crystal shape in zebrafish iridosomes, finding that crystal growth along the b-axis is controlled by purine molecular interactions.

Visualizing sub-organellar lipid distribution using correlative light and electron microscopy

This paper introduces a correlative light and electron microscopy workflow to quantify lipid densities in membrane nanodomains and finds sphingomyelin partitions into specific endosomal structures.

Cell free expression in proteinosomes prepared from native protein-PNIPAAm conjugates

This study demonstrates cell-free transcription and translation in proteinosomes made from native protein-polymer conjugates, showing enhanced stability and expression compared to traditional methods.

A local insulin reservoir ensures developmental progression in condition of nutrient shortage in Drosophila

The paper shows that Dilps are stored in the Corpora Cardiaca and released during nutrient shortage to activate IIS in the prothoracic gland, accelerating pupal development.

Metabolic control of YAP via the acto-myosin system during liver regeneration

The paper investigates how the acto-myosin system regulates YAP activity during liver regeneration in response to bile acid overload.