Pauline Wimberger

Prospective pan-cancer phosphoproteomics at clinical scale extends therapeutic options in precision oncology

This study uses pan-cancer phosphoproteomics to identify therapeutic targets and improve precision oncology by analyzing 1,998 tumor samples and developing new scores for kinase activity and immune response.

Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephalic cortical malformation

The paper uses cerebral organoids from patients with actin mutations to show that altered cleavage plane orientation in ventricular zone progenitors leads to microcephaly.

Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolution

This study identifies human-specific morphoregulatory signatures in basal radial glia that drive neocortex evolution through comparative chromatin and transcriptional profiling.

Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate

The paper compares the roles of canonical and non-canonical PRC1 sub-complexes in neural stem cell regulation during neocortex development, finding canonical PRC1 has a more significant impact.

Epigenome profiling identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis

The paper identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis using Epi-CyTOF and cortical organoids.

Primate-expressed EPIREGULIN promotes basal progenitor proliferation in the developing neocortex

This study shows that primate-specific EPIREGULIN expression enhances basal progenitor proliferation in the developing neocortex, contributing to increased brain size across species.

Longer metaphase and fewer chromosome segregation errors in modern human than Neandertal brain development

This study introduces modern human-specific amino acid substitutions into mice and human brain organoids, showing improved chromosome segregation fidelity in modern humans compared to Neandertals.

YAP activity is necessary and sufficient for basal progenitor abundance and proliferation in the developing neocortex

This study shows YAP activity is necessary and sufficient for basal progenitor proliferation and abundance in the developing neocortex, linking it to neocortical expansion during evolution.

Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex

The paper identifies human-specific genes preferentially expressed in fetal neocortex progenitors and shows they have distinct cell-type specificity compared to ancestral paralogs.