Mechanism of activation of an ancestral Tec kinase by PIP3
Eva Krötenheerdt, Lucas Piëch, Freia von Raußendorf, Ronja Reinhardt, Ranjana Nataraj, Nicholas Wedige, Hunter G. Nyvall, Emma E. Walsh, John E. Burke, Thomas A. Leonard
This study identifies how PIP3 activates an ancestral Tec kinase by displacing its PH domain from an inhibitory interaction with its kinase domain.
npj Structural Biology · Oct 1, 2026Peer-reviewedBiochemistry