Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
Aaron L. Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J. Knox, Anand K. Muthusamy, Jonathan S. Marvin, Charlene H. Kim, Stephen N. Grant, David P. Walton, Bruce N. Cohen, Rebekkah Hammar, Loren L. Looger, Per Artursson, Dennis A. Dougherty, Henry A. Lester
This study measures the temporal dynamics of SSRIs in different cellular compartments and shows they accumulate in membranes and organelles, suggesting new roles in therapeutic effects and discontinuation syndrome.
Journal of Neuroscience · Mar 3, 2023Peer-reviewedNeuroscience