Jonathan S. Marvin

The paper develops and validates a genetically encoded fluorescent sensor, iG6PSnFR, for measuring glucose-6-phosphate dynamics across multiple biological contexts.

The paper measures the energy cost of learning-based tasks in mice and finds that post-learning fuel consumption decreases, suggesting energy minimization during learning.

The paper introduces OCaMP, an orange fluorescent calcium indicator that improves sensitivity and performance compared to existing green and red indicators for neural imaging.

The paper develops two variants of a glutamate indicator with enhanced sensitivity and tailored deactivation rates for studying synaptic transmission in vivo.

The paper improves a GABA sensor, iGABASnFR2, with higher sensitivity and faster kinetics, enabling better in vivo imaging of GABAergic transmission.

This study develops a fluorescent opioid biosensor to measure fentanyl levels in mice and links pharmacokinetics to behavioral patterns using computational ethology.

The paper uses fluorescent sensors to study glutamate and GABA dynamics during interictal spikes and seizures in a rodent model, revealing a progressive failure of inhibitory restraint leading to seizures.

This paper develops improved glutamate indicators with faster activation kinetics and better synaptic localization for imaging synaptic transmission in neurons.

The paper shows that volume-transmitted GABA waves drive epileptiform rhythms in hippocampal networks by elevating tonic GABAA receptor conductance across multiple cells.

This study measures the temporal dynamics of SSRIs in different cellular compartments and shows they accumulate in membranes and organelles, suggesting new roles in therapeutic effects and discontinuation syndrome.

GESIAP is a MATLAB-based image analysis program that processes genetically encoded sensor data to analyze neuromodulator transmission properties across cell types and species.

The paper introduces jYCaMP1, a calcium indicator optimized for two-photon imaging at wavelengths above 1000 nm, showing improved performance in mice and flies.

iAChSnFR, a fluorescent indicator built from a bacterial periplasmic binding protein, reports acetylcholine with large, fast signals in mouse, fish, fly and worm preparations.

This paper introduces a two-photon imaging technique that achieves high-speed, high-resolution imaging of neural activity in mice at over 1 kHz frame rates.

This paper develops a genetically encoded fluorescent sensor, iGABASnFR, to monitor GABA in vivo and demonstrates its use in tracking GABA dynamics in various neural contexts.

The paper uses multiplex imaging to simultaneously measure presynaptic Ca2+ and glutamate release at multiple synapses in situ.

This paper develops a genetically encoded glucose sensor for in vivo imaging across multiple organisms, revealing novel glucose dynamics in neurons, astrocytes, and zebrafish.

The paper introduces variants of the glutamate sensor iGluSnFR with improved brightness, broader concentration detection, and different emission colors for enhanced in vivo imaging.