Per Artursson

This study establishes human apical-out ileal organoids as a model to study gut-nanomaterial interactions, showing charge-selective uptake regulated by the glycocalyx.

This study identifies that a minimal glycocalyx on host cell membranes optimally facilitates Salmonella Typhimurium targeting, with glycoproteins and cholesterol playing key roles.

This study uses proteomic profiling to identify age-related changes in transporter proteins in human brain microvessels, revealing alterations in BBB permeability and drug disposition.

This study shows that maturation of human intestinal epithelial cells reduces susceptibility to Salmonella invasion by altering actin regulation, mucin expression, and glycocalyx composition.

This study establishes and characterizes human jejunal enteroids for studying epithelial drug transport and metabolism, showing they recapitulate in vivo features and accurately predict drug pharmacokinetics.

This study measures the temporal dynamics of SSRIs in different cellular compartments and shows they accumulate in membranes and organelles, suggesting new roles in therapeutic effects and discontinuation syndrome.