Anand K. Muthusamy

Using Latent Chemical Recognition in an Evolved Periplasmic Binding Protein Family to Diversify Biosensors

The paper screens a family of evolved biosensors against diverse ligands to identify cross-reactive compounds, finding multiple ligands beyond neural drugs that activate the sensors.

Correspondence of fentanyl brain pharmacokinetics and behavior measured via engineering opioids biosensors and computational ethology

This study develops a fluorescent opioid biosensor to measure fentanyl levels in mice and links pharmacokinetics to behavioral patterns using computational ethology.

Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane

This study measures the temporal dynamics of SSRIs in different cellular compartments and shows they accumulate in membranes and organelles, suggesting new roles in therapeutic effects and discontinuation syndrome.