Author

P. Hemachandra Reddy

Texas Tech UniversityORCID 0000-0002-9560-9948Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Neha A. Sawant· 3 shared Chhanda BoseiD· 2 shared Erika Orlov· 2 shared Hallie Morton· 2 shared Jangampalli Adi PradeepkiraniD· 2 shared Lloyd E. Bunquin· 2 shared Subodh KumariD· 2 shared Sudhir KshirsagariD· 2 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Neha A. Sawant

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Synaptosome microRNAs regulate synapse functions in Alzheimer's disease

Subodh Kumar, Erika Orlov, Prashanth Gowda, Chhanda Bose, Russell Howard Swerdlow, Debomoy K. Lahiri, P. Hemachandra Reddy

The paper compares miRNA expression in synaptosomes and cytosol from AD and control brains, identifying differentially expressed miRNAs and their potential roles in synapse function.

npj Genomic Medicine · Aug 8, 2022Peer-reviewedNeuroscience

Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease

Sanjay Awasthi, Ashly Hindle, Neha A. Sawant, Mathew George, Murali Vijayan, Sudhir Kshirsagar, Hallie Morton, Lloyd E. Bunquin, Philip Palade, J. Josh Lawrence, Hafiz Mohammad Rafiqullah Khan, Chhanda Bose, P. Hemachandra Reddy, Sharda Prakash Singh

This study investigates the role of Rlip in oxidative stress and mitochondrial dysfunction in Alzheimer's disease by analyzing Rlip-deficient mice and finding cognitive decline and mitochondrial alterations.

Cells · Nov 10, 2021Peer-reviewedNeuroscience

Mitophagy enhancers against phosphorylated Tau-induced mitochondrial and synaptic toxicities in Alzheimer disease

Sudhir Kshirsagar, Neha A. Sawant, Hallie Morton, Arubala P. Reddy, P. Hemachandra Reddy

This study evaluates mitophagy enhancers' ability to mitigate P-tau-induced mitochondrial and synaptic damage in AD using HT22 neurons, showing improved cell survival and mitochondrial function.

Pharmacological Research · Nov 8, 2021Peer-reviewedNeuroscience

A partial reduction of Drp1 enhances mitophagy, autophagy, mitochondrial biogenesis, dendritic spines and synaptic activity in a transgenic Tau mouse model of Alzheimer disease

Ramesh J. L. Kandimalla, Maria Mańczak, Jangampalli Adi Pradeepkiran, P. Hemachandra Reddy

This study shows that reducing Drp1 in Tau mice improves cognitive function and mitochondrial health by enhancing autophagy, mitophagy, and synaptic activity.

bioRxiv · Oct 7, 2021 · PreprintNeuroscience

Novel microRNA-455-3p mouse models to study Alzheimers disease pathogenesis

Subodh Kumar, Hallie Mortan, Neha A. Sawant, Erika Orlov, Lloyd E. Bunquin, Jangampalli Adi Pradeepkiran, P. Hemachandra Reddy

This study generates miR-455-3p transgenic and knockout mouse models to investigate their role in Alzheimer's disease pathogenesis, showing protective and deleterious effects respectively.

bioRxiv · Sep 23, 2021 · PreprintNeuroscience