Programmable translational inhibition by a molecular glue-oligonucleotide conjugate
Siyi Wang, Joanna R. Kovalski, Francisco José Zapatero Belinchón, Maxwell Bennett, Duygu Kuzuoğlu‐Öztürk, Qiongyu Li, Erica J. Stevenson, Jie Liu, Nevan J. Krogan, Mélanie Ott, Danielle L. Swaney, Davide Ruggero, Kevin Lou, Kevan M. Shokat
This paper develops RocASO, a molecular glue-oligonucleotide conjugate that selectively inhibits mRNA translation by targeting specific sequences, showing potent antiviral activity against SARS-CoV-2.
bioRxiv · Jul 15, 2025 · PreprintGenomics