Kevin Lou

This paper identifies BisRoc, a dimeric rocaglate ligand that suppresses translation more potently and specifically than monomeric RocA by promoting multivalent eIF4A-RNA assembly.

This study uses GENEVA to analyze drug response variations in cancer cells, revealing mitochondrial activation's role in KRAS inhibition and EMT as a resistance mechanism.

This paper develops RocASO, a molecular glue-oligonucleotide conjugate that selectively inhibits mRNA translation by targeting specific sequences, showing potent antiviral activity against SARS-CoV-2.

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

The paper uses deep mutational scanning to explore how chemical perturbations affect ubiquitin's mutational tolerance, revealing sensitization of most positions except two.