Author

Daniel Espiritu

Queen's UniversityORCID 0000-0002-9580-6132Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Anna R. PanchenkoiD· 1 shared Daria S. OstroverkhovaiD· 1 shared David LandsmaniD· 1 shared Maria J. AristizabaliD· 1 shared Shuxiang LiiD· 1 shared Yiru ShengiD· 1 shared Yunhui PengiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Anna R. PanchenkoORCID

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1 paper

Recent·Most cited

BioinformaticsNucleic Acids ResearchPeer-reviewedAug 27, 2025

Cancer Histone Mutations Impact Binding and DNA Repair Processes, Leading to Increased Mutagenesis

Daniel Espiritu, Yiru Sheng, Yunhui Peng…·Anna R. Panchenko

The paper assesses the oncogenic potential of histone missense mutations using whole-exome sequencing data from over 12,000 cancer patients, finding that these mutations affect DNA repair interactions and increase mutagenesis.

11 citationstop 4%

humanwhole-exome sequencing

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