Shuxiang Li

Molecular Dynamics-Guided All-Atom Reconstruction of Cryo-ET Maps Reveals Mechanisms of Histone Tail-Mediated Chromatin Compaction

This study uses molecular dynamics and cryo-ET to show histone tails drive chromatin compaction through specific interactions, revealing their role in both structural organization and nucleosome communication.

Cancer Histone Mutations Impact Binding and DNA Repair Processes, Leading to Increased Mutagenesis

The paper assesses the oncogenic potential of histone missense mutations using whole-exome sequencing data from over 12,000 cancer patients, finding that these mutations affect DNA repair interactions and increase mutagenesis.

Genome-wide Nucleosome Positioning and Associated Features uncovered with Interpretable Deep Residual Networks

The paper introduces NuPose, a deep residual network for predicting nucleosome positions and associated features across the genome with high accuracy.

Survivin prevents the Polycomb Repressor Complex 2 from methylating Histone 3 lysine 27

The paper shows survivin interacts with PRC2, preventing H3K27 methylation and gene silencing in CD4+T cells.