Daria S. Ostroverkhova

The paper assesses the oncogenic potential of histone missense mutations using whole-exome sequencing data from over 12,000 cancer patients, finding that these mutations affect DNA repair interactions and increase mutagenesis.

The paper evaluates domain-based methods for identifying cancer driver mutations by aggregating mutations across protein domains and mutation types, finding improved classification performance with domain similarity.

This study evaluates next-generation pathogenicity predictors for cancer driver mutation detection, finding they perform well but lack specificity for cancer types.