Ronald E. van Kesteren

Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer's disease

The paper shows that in a mouse model of Alzheimer's disease, remote memory decline with age is linked to increased inhibition of cortical engram cells by hyperexcitable parvalbumin interneurons.

One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation

This study develops a single-step transposon-based method to generate pure GABAergic neurons from iPSCs, showing they mature synaptically and form functional networks.

Single-cell RNA sequencing data reveals rewiring of transcriptional relationships in Alzheimer's Disease associated with risk variants

The paper uses scRNA-seq data to identify gene expression rewiring in Alzheimer's Disease linked to risk variants by analyzing differential correlations across cell types.