Shivali Gupta

Spatial transcriptomic profiling identifies lacrimal gland epithelial cell-driven mechanisms underlying autoimmunity in Sjogrens disease.

This study uses spatial transcriptomics to identify epithelial cell-driven mechanisms in Sjogrens disease, revealing new insights into autoimmune pathology and potential therapeutic targets.

Clusterin reverses epitheliopathy, reduces inflammation, and restores goblet cells and corneal nerves in a mouse model of autoimmune dry eye

This study tests clusterin's therapeutic effects in a mouse model of autoimmune dry eye, finding it improves corneal barrier function, nerve density, and goblet cell regeneration while reducing inflammation, comparable to dexamethasone.