Author

Danny Farhat

University of OttawaORCID 0000-0002-9600-7973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Jyh‐Yeuan LeeiD· 2 shared Fatemeh RezaeiiD· 1 shared Isra F Omar· 1 shared Kadambari Vijay Sai· 1 shared Qing-Fang Xiao· 1 shared Sai Anvithaa Sundar Rajan· 1 shared Shang‐Te Danny HsuiD· 1 shared Yuan‐Chih ChangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Jyh‐Yeuan LeeORCID

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2 papers

Recent·Most cited

A Sterol-Binding Cavity Underlies Sterol Recognition and Differential Activation of the ABCG5/G8

Fatemeh Rezaei, Isra F Omar, Danny Farhat, Zi-Wen Weng, Kadambari Vijay Sai, Qing-Fang Xiao, Yuan‐Chih Chang, Shang‐Te Danny Hsu, Jyh‐Yeuan Lee

This study determines the cryo-EM structure of ABCG5/G8 with ergosterol and shows that ergosterol activates the transporter more than cholesterol or CHS, with Y432 in the aromatic clamp playing a key role.

bioRxiv · Aug 11, 2026 · PreprintBiochemistry

Structural Determinants for the Monomeric and Phospholipid-Transport P4B-ATPase via comprehensive in silico analysis of P4-ATPase structures.

Danny Farhat, Sai Anvithaa Sundar Rajan, Jyh‐Yeuan Lee

This study identifies structural determinants of P4B-ATPases through in silico analysis, revealing unique features that may underlie their monomeric phospholipid transport mechanism.

Biochemistry and Cell Biology · Jan 1, 2026Peer-reviewedBiochemistry