Author
Hiroshima UniversityORCID 0000-0002-7231-0185Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Fatemeh Rezaei, Isra F Omar, Danny Farhat, Zi-Wen Weng, Kadambari Vijay Sai, Qing-Fang Xiao, Yuan‐Chih Chang, Shang‐Te Danny Hsu, Jyh‐Yeuan Lee
This study determines the cryo-EM structure of ABCG5/G8 with ergosterol and shows that ergosterol activates the transporter more than cholesterol or CHS, with Y432 in the aromatic clamp playing a key role.
bioRxiv · Aug 11, 2026 · PreprintBiochemistry
Rishi S. Patel, Nipuni M. Pannala, Chih-Hsuan Lai, Manoj Kumar Sriramoju, Yongsheng Wang, Ting Cheng, Dabin Jung, Payam Kelich, Soroush Asadi, Elizaveta I. Shestoperova, Shalini Iyer, Emad Tajkhorshid, Daniel Patrick Flaherty, Eric R. Strieter, Shang‐Te Danny Hsu, Chittaranjan Das
This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.
bioRxiv · Jul 16, 2026 · PreprintBiochemistry
Piotr Drączkowski, Szu-Ni Chen, Ting Chen, Yong‐Sheng Wang, Hsin-An Shih, Jessica Y. C. Huang, Ming-Chieh Tsai, Shu‐Yu Lin, Steven Lin, Rosa Viner, Yuan‐Chih Chang, Kuen‐Phon Wu, Shang‐Te Danny Hsu
The paper reports cryo-EM structures of the human 26S proteasome bound to K11/K48-branched ubiquitin chains, revealing a multivalent recognition mechanism involving new binding sites for K11 and alternating K11-K48 linkages.
Nature Communications · Oct 15, 2025Peer-reviewedBiochemistry
Cristina Paissoni, Sarita Puri, Luca Broggini, Manoj Kumar Sriramoju, Martina Maritan, Rosaria Russo, Valentina Speranzini, Federico Ballabio, Mario Nuvolone, Giampaolo Merlini, Giovanni O. Palladini, Shang‐Te Danny Hsu, Stéfano Ricagno, Carlo Camilloni
This study identifies a conformational fingerprint distinguishing AL from MM light chains using SAXS and MD simulations, revealing a unique H state in AL LCs.
bioRxiv · Jul 12, 2024Biophysics