BiochemistrybioRxivPreprint
A Sterol-Binding Cavity Underlies Sterol Recognition and Differential Activation of the ABCG5/G8
Fatemeh Rezaei, Isra F Omar, Danny Farhat…·Jyh‐Yeuan Lee
This study determines the cryo-EM structure of ABCG5/G8 with ergosterol and shows that ergosterol activates the transporter more than cholesterol or CHS, with Y432 in the aromatic clamp playing a key role.