Jyh‐Yeuan Lee

This study determines the cryo-EM structure of ABCG5/G8 with ergosterol and shows that ergosterol activates the transporter more than cholesterol or CHS, with Y432 in the aromatic clamp playing a key role.

This study identifies structural determinants of P4B-ATPases through in silico analysis, revealing unique features that may underlie their monomeric phospholipid transport mechanism.