Reversible m6Am methylation of snRNA by FTO controls morphine reward and tolerance without altering analgesia
Shan Liu, Ayma F. Malik, Raymond Chien, Jianheng Fox Liu, Louise V. B. Nicholson, Jin Xu, Kimia Didehvar, Vipin Rai, Valerie P. Le Rouzic, Arlene Martínez-Rivera, Konstantinos Boulias, Bing Wang, Anjali M. Rajadhyaksha, Yuan-Xian Tao, Eric Lieberman Greer, , Ying‐Xian Pan
This study shows that FTO regulates morphine reward and tolerance through m6Am methylation of snRNA, without affecting analgesia.
bioRxiv · Aug 12, 2026 · PreprintNeuroscience