Louise V. B. Nicholson

This study shows that FTO regulates morphine reward and tolerance through m6Am methylation of snRNA, without affecting analgesia.

The paper evaluates Dorado basecalling for nanopore DRS to detect m6A modifications in RNA, finding that stringent filtering improves accuracy and revealing cell-type differences in m6A proportions at conserved sites.

This study reassesses FTO's role as an m6A eraser in AML using direct RNA nanopore sequencing, finding no effect on m6A stoichiometry but increased m6Am levels.

The paper introduces CROWN-seq to map m6Am modifications and transcription-start sites in human cell lines, revealing high stoichiometry and links to transcription initiation.