Lindsay M. Klouser

This study shows that the R2 mutation in UL37 of HSV-1 strain 17+ only partially blocks retrograde transport, allowing latency and reactivation in mouse models.

This study shows that restricting meganuclease expression to specific tissues reduces off-target gene editing in vivo.

This study shows that AAV-delivered gene editing reduces latent HSV DNA in mice and decreases viral shedding, with some toxicity observed at high doses.