Hong Jian Xie

This study shows that the R2 mutation in UL37 of HSV-1 strain 17+ only partially blocks retrograde transport, allowing latency and reactivation in mouse models.

This study introduces two novel amplicon sequencing schemes for RSV A and B, demonstrating their effectiveness in generating high-quality genomes globally and revealing minimal geographic clustering of RSV sequences.

The paper evaluates a tiling amplicon panel for RSV whole genome sequencing, showing high sensitivity, specificity, and accuracy in clinical and contrived samples.

This study shows that restricting meganuclease expression to specific tissues reduces off-target gene editing in vivo.

The paper analyzes Treponema pallidum genomic data from Seattle to identify strain circulation and tprK antigen variation patterns in syphilis cases.

The paper reports a case of HSV mistyping caused by HSV-1 x HSV-2 recombination in the UL27 gene, which is important for diagnostics and therapeutics.

This study identifies tissue-specific RNA expression of integrated HHV-6A/B in vivo and links it to increased antibody responses against specific viral antigens.

This study identifies interspecies recombination events in HSV-2 genomes and shows their impact on genetic variation and T-cell recognition.

The paper develops tools to directly sequence HSV genomes from clinical samples with high sensitivity and low viral load, revealing limited evolution during cell culture.

The paper uses next-generation sequencing to analyze copy number variations and interspecies recombination in HHV-6A and HHV-6B reference strains, revealing large tandem repeats and a novel recombinant strain.