Author

Lauren A. McCarthy

University of MichiganORCID 0000-0002-9646-5333Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 3 Organism:E. coli· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Julie S. BiteeniD· 4 shared Lindsey E. WayiD· 4 shared Xindan WangiD· 4 shared Anne S. MeyeriD· 2 shared David E.H. Fuller· 2 shared Elio A. AbbondanzieriiD· 2 shared Emma E. WiesleriD· 2 shared Gail G. HardyiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersBiophysics

Julie S. BiteenORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Characterizing the Impact of Nucleoid-Associated Proteins on HU-DNA Interactions by Live-Cell Single-Molecule Tracking

D E H Fuller, Dai Xin, Lauren A. McCarthy, Lindsey E. Way, Xindan Wang, Julie S. Biteen

This study uses live-cell single-molecule tracking to analyze how NAPs like Dps and H-NS affect HU-DNA interactions across different growth phases in E. coli.

ChemPhysChem · Apr 29, 2026Peer-reviewedBiophysics

The biophysical properties of the bacterial nucleoid are dynamic, heterogeneous, and responsive to perturbations of cellular processes

Xiaofeng Dai, Lauren A. McCarthy, Lindsey E. Way, Emma E. Wiesler, Qin Liao, Xindan Wang, Julie S. Biteen

This study measures the biophysical properties of the bacterial nucleoid and shows they are dynamic, heterogeneous, and responsive to cellular processes.

bioRxiv · Feb 19, 2026 · PreprintBiophysics

Dps binds and protects DNA in starved Escherichia coli with minimal effect on chromosome accessibility, dynamics and organisation

Lauren A. McCarthy, Lindsey E. Way, Xiaofeng Dai, Zhongqing Ren, David E.H. Fuller, Ishika Dhiman, Linaria Larkin, Jurriaan J. D. Sieben, Ilja Westerlaken, Elio A. Abbondanzieri, Gail G. Hardy, Anne S. Meyer, Xindan Wang, Julie S. Biteen

This study shows Dps compacts the E. coli nucleoid and increases short-range DNA interactions without significantly affecting chromosome accessibility, dynamics, or organisation.

Nucleic Acids Research · Dec 10, 2025Peer-reviewedBiophysics

Genome-wide DNA bridging by H-NS reshapes the stationary phase nucleoid and transcriptional landscape

Lindsey E. Way, Xiaofeng Dai, Emma E. Wiesler, Lauren A. McCarthy, Zhongqing Ren, Gail G. Hardy, David E.H. Fuller, Labeeb Hossain, Anne S. Meyer, Elio A. Abbondanzieri, Julie S. Biteen, Xindan Wang

This study shows H-NS bridges DNA in the stationary-phase nucleoid of E. coli, leading to transcriptional repression and a shifted gene expression landscape.

bioRxiv · Oct 14, 2025 · PreprintMolecular Biology