PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins
Christopher R. Horne, Toby A. Dite, Samuel N. Young, Lucy J. Mather, Laura F. Dagley, Jared Lee Johnson, Tomer M. Yaron, Emily M. Huntsman, Leonard A. Daly, Dominic P. Byrne, Antonia L. Cadell, Boaz H. Ng, Jumana M. Yousef, Dylan H. Multari, Lianju Shen, , James M. Murphy
The paper identifies allosteric regulation of PSKH1 kinase activity by Ca2+ sensor proteins, showing both activation and suppression by different sensors.
Proceedings of the National Academy of Sciences · Feb 18, 2025Peer-reviewedBiochemistry