Author

Lucy J. Mather

Walter and Eliza Hall Institute of Medical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Christopher R. HorneiD· 3 shared James M. MurphyiD· 3 shared Samuel N. YoungiD· 3 shared Gerard ManningiD· 2 shared John W. ScottiD· 2 shared Laura F. DagleyiD· 2 shared Toby A. DiteiD· 2 shared Abner Gonzalez Castro· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

Christopher R. HorneORCID

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Author profile →

3 papers

Recent·Most cited

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

Jiyi Pang, Aysha Al‐Ani, Komal M. Patel, Yunzhuo Zhou, Samuel N. Young, Jinjin Chen, Isabella Y. Kong, Marilou H. Barrios, James A. Rickard, Siqi Chen, Xiuquan Ma, Farzaneh‐Sadat Rezazadeh‐Shojaee, Seong-Beom Kim, Siavash Foroughi, Wayne Cawthorne, , James M. Murphy

This study identifies dysregulated epithelial cell death signaling in inflammatory bowel disease, showing it persists during remission despite therapy.

Science · Aug 27, 2026Peer-reviewedCell Biology

Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity

Christopher R. Horne, Tingting Wang, Samuel N. Young, Toby A. Dite, Hunter G. Nyvall, Sushant Suresh, Katherine A. Davies, Abner Gonzalez Castro, Vineet Vaibhav, Lucy J. Mather, Laura F. Dagley, Matthew J. Belousoff, Gerard Manning, Anthony R. Means, John E. Burke, , James M. Murphy

The paper identifies an unconventional mechanism where Ca2+-CaM binds CHK2 kinase to inhibit its activity, contrasting with its typical role in promoting kinase activity.

Biochemical Journal · Sep 26, 2025Peer-reviewedBiochemistry

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

Christopher R. Horne, Toby A. Dite, Samuel N. Young, Lucy J. Mather, Laura F. Dagley, Jared Lee Johnson, Tomer M. Yaron, Emily M. Huntsman, Leonard A. Daly, Dominic P. Byrne, Antonia L. Cadell, Boaz H. Ng, Jumana M. Yousef, Dylan H. Multari, Lianju Shen, , James M. Murphy

The paper identifies allosteric regulation of PSKH1 kinase activity by Ca2+ sensor proteins, showing both activation and suppression by different sensors.

Proceedings of the National Academy of Sciences · Feb 18, 2025Peer-reviewedBiochemistry