Emily M. Huntsman

HIV Nef amplifies mechanical heterogeneity to promote immune evasion

This study shows HIV Nef induces a soft phenotype in infected CD4+ T cells, reducing their susceptibility to cytotoxic T lymphocyte killing through cytoskeletal remodeling and intrinsic heterogeneity.

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

The paper identifies allosteric regulation of PSKH1 kinase activity by Ca2+ sensor proteins, showing both activation and suppression by different sensors.

A global atlas of substrate specificities for the human serine/threonine kinome

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.