Quantitative modeling of P-TEFb mediated CTD phosphorylation identifies local cooperativity
Aaron Callenbach, Domagoj Dorešić, Robert Düster, Vanessa Nakonecnij, Erika Dudkin, Matthias Geyer, Jan Hasenauer
The paper uses mathematical modeling to show P-TEFb phosphorylates CTD repeats with local cooperativity but no directional bias.
bioRxiv · Dec 2, 2025 · PreprintSystems Biology