Collins Osei-Sarpong

The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease

This study shows NF-Y promotes myeloid cell survival and protects against inflammatory vascular disease by regulating transcriptional states in atherosclerosis.

Downregulation of Satb1 is required to prevent autoimmunity by maintaining Tfh homeostasis

This study shows that Satb1 downregulation prevents autoimmunity by maintaining Tfh cell homeostasis and preventing excessive GC formation and auto-antibody secretion.

The nuclear receptor NR4A1 serves as a neutrophil-intrinsic regulator mitigating stroke severity

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

Molecular determinants of brain-resident CD8+ T cell formation and function

This study identifies molecular factors shaping brain-resident CD8+ T cell formation and function in health and disease.

Disease-associated microglia and activation of CD8+ T cells precede neuronal cell loss in a model of hereditary spastic paraplegia

Divergent granulopoiesis at extramedullary sites safeguards host defense

This study shows that the spleen produces neutrophils with distinct differentiation trajectories during stress, which are functionally competent and necessary for host defense against bacterial infection.

Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

The paper identifies fetal liver macrophage subpopulations and shows their role in regulating granulopoiesis and the HSC niche during embryogenesis.

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease

This study uses single-cell RNA-seq and computational methods to analyze macrophage states in COPD patients, revealing transcriptional changes and metabolic shifts associated with the disease.