Author

Xiaopeng Li

Michigan State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Bioinformatics· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:large language model· 1

Frequent Co-Authors

Bin CheniD· 3 shared Dmitry LeshchineriD· 2 shared Jing PuiD· 2 shared Li Huang· 2 shared Rama ShankariD· 2 shared Shubham KoiralaiD· 2 shared Xiaodan Zhang· 2 shared Yuying XieiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersBioinformatics

Bin ChenORCID

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Author profile →

3 papers

Recent·Most cited

In Vivo Transcriptomics-Based Framework for Systematic Indication Expansion

Zsolt Palmer, Shubham Koirala, Nabasmita Talukdar, Xiaodan Zhang, Hannah S. Garver, McKenzie Mahlmeister, Li Huang, Dimitri Joseph, Dmitry R. Leshchiner, Rama Shankar, Stephanie Wengert Watts, Xiaopeng Li, Benjamin Scott Glicksberg, Adam A Lauver, Bin Chen

This paper presents a drug repurposing framework using in vivo transcriptomics to expand indications by matching drug signatures with disease signatures, successfully recovering established uses of semaglutide and proposing new ones.

bioRxiv · Oct 14, 2026 · PreprintSystems Biology

A pretrained unified model enables cellular functional profile prediction and multi-objective virtual drug screening

Ruoqiao Chen, Li Huang, Yu Qiao, Saurabh Mandal, Linqing Mo, Lingxiao Li, Dmitry Leshchiner, Xiaodan Zhang, Jing Pu, Yuying Xie, Reda E. Girgis, Edmund L. Ellsworth, Ling Huang, Xin Chen, Xiaopeng Li, , Bin Chen

InsilicoCell predicts cellular functional profiles and enables multi-objective virtual drug screening by integrating diverse molecular data and tasks.

bioRxiv · Aug 28, 2026 · PreprintBioinformatics

Automating scientific annotations for open transcriptomic profiles via multi-stage agents

X C Zhang, Shreya Paithankar, Jing Pu, Mehtab Sardar Murtaza, Rama Shankar, Dmitry Leshchiner, Shubham Koirala, Zsolt Palmer, Rance Nault, Xiaopeng Li, Yuying Xie, Bin Chen

GEOMeta automates metadata curation for GEO transcriptomic data, generating standardized annotations for 600,000 human bulk RNA-seq samples and benchmarking LLMs for annotation quality.

bioRxiv · Aug 20, 2026 · PreprintBioinformatics