Author

Xiaodan Zhang

Michigan State UniversityPrimary ORCID profile (0000-0001-8192-0666 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Xiaodan ZhangiD3 papers · Cornell University

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Bin CheniD· 2 shared Li Huang· 2 shared Xiaopeng Li· 2 shared Adam A LauveriD· 1 shared Benjamin Scott GlicksbergiD· 1 shared Dimitri Joseph· 1 shared Dmitry LeshchineriD· 1 shared Dmitry R. LeshchineriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersSystems Biology

Bin ChenORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

In Vivo Transcriptomics-Based Framework for Systematic Indication Expansion

Zsolt Palmer, Shubham Koirala, Nabasmita Talukdar, Xiaodan Zhang, Hannah S. Garver, McKenzie Mahlmeister, Li Huang, Dimitri Joseph, Dmitry R. Leshchiner, Rama Shankar, Stephanie Wengert Watts, Xiaopeng Li, Benjamin Scott Glicksberg, Adam A Lauver, Bin Chen

This paper presents a drug repurposing framework using in vivo transcriptomics to expand indications by matching drug signatures with disease signatures, successfully recovering established uses of semaglutide and proposing new ones.

bioRxiv · Oct 14, 2026 · PreprintSystems Biology

A pretrained unified model enables cellular functional profile prediction and multi-objective virtual drug screening

Ruoqiao Chen, Li Huang, Yu Qiao, Saurabh Mandal, Linqing Mo, Lingxiao Li, Dmitry Leshchiner, Xiaodan Zhang, Jing Pu, Yuying Xie, Reda E. Girgis, Edmund L. Ellsworth, Ling Huang, Xin Chen, Xiaopeng Li, , Bin Chen

InsilicoCell predicts cellular functional profiles and enables multi-objective virtual drug screening by integrating diverse molecular data and tasks.

bioRxiv · Aug 28, 2026 · PreprintBioinformatics