NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms
Ruth-Miriam Koerber, Calvin Krollmann, Kevin Cieslak, Elisabeth Tregel, Maria L. Saenz, Tim H. Brümmendorf, Steffen Koschmieder, Martin Grießhammer, Ines Gütgemann, Conny K. Baldauf, Thomas Fischer, Peter Brossart, Carl Christian Kolbe, Eicke Latz, Dominik Georg Friedrich Wolf, Lino Lars Teichmann
This study shows that NLRP3 inflammasome activation drives JAK2V617F mutant myeloproliferative neoplasms by promoting inflammation, platelet production, and fibrosis, and that its inhibition can reverse disease features.
Nature Communications · Nov 26, 2025Peer-reviewedCancer Biology