Cell type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening
Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, Eric Wang, Theodore Sakellaropoulos, Francesco E. Boccalatte, Palaniraja Thandapani, Jane A. Skok, Iannis Aifantis, David Fenyö, Bo Xia, Aristotelis Tsirigos
This study introduces C.Origami, a deep learning model that predicts cell type-specific 3D chromatin organization, enabling in silico genetic screening to identify genomic regions affecting chromatin structure.
Nature Biotechnology · Jan 9, 2023Peer-reviewedGenomics