Javier Rodriguez-Hernaez

This study introduces C.Origami, a deep learning model that predicts cell type-specific 3D chromatin organization, enabling in silico genetic screening to identify genomic regions affecting chromatin structure.

The paper investigates the distinct and combined roles of CTCF and CTCFL in chromosome organization and transcription by analyzing their binding sites and functional domains.

The paper shows NSD2 overexpression alters chromatin structure and gene expression by affecting CTCF and H3K27ac in specific chromatin domains.

The paper shows that CTCF's RNA-binding ability is crucial for its chromatin association and insulation function.