ImmunologybioRxiv
GPCR-Ga13 signaling regulates survival of intestinal intraepithelialCD8 lymphocytes through migration to cytokine-rich niches
Zachary M. Earley, Anshul Rao, Longhui Qiu…·Jason G. Cyster
This study shows that GPCR-Ga13 signaling is essential for intestinal IEL survival by enabling migration to cytokine-rich niches, with loss of G13 leading to impaired function and increased disease severity.
DOI 10.1016/j.immuni.2026.07.021