GPCR-Ga13 signaling regulates survival of intestinal intraepithelialCD8 lymphocytes through migration to cytokine-rich niches
Zachary M. Earley, Anshul Rao, Longhui Qiu, Konrad Knöpper, Fanglue Peng, Norihide Jo, Ananya Krishnapura, Wioletta Lisicka, Hanna Taglinao, Jinping An, Ying Xu, Li V. Yang, Dan Liu, Mark R. Looney, Jason G. Cyster
This study shows that GPCR-Ga13 signaling is essential for intestinal IEL survival by enabling migration to cytokine-rich niches, with loss of G13 leading to impaired function and increased disease severity.
bioRxiv · Aug 3, 2026Immunology