Author

Hannah Peckham

Great Ormond Street HospitalORCID 0000-0002-9668-4683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:imputation· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Anna RadziszewskaiD· 2 shared Claire T. DeakiniD· 2 shared Coziana CiurtiniD· 2 shared Emma S. ChambersiD· 2 shared Justyna SikoraiD· 2 shared Lucy R. WedderburniD· 2 shared Melissa KartawinataiD· 2 shared Restuadi RestuadiiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Anna RadziszewskaORCID

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3 papers

Recent·Most cited

Age-associated inflammatory monocytes are increased in menopausal females and reversed by Hormone Replacement Therapy

Roel P. H. De Maeyer, Justyna Sikora, Olivia V. Bracken, Barbara Bo-Ju Shih, Amy F. Lloyd, Hannah Peckham, Kate Hollett, K Abdelhamid, Weigang Cai, Michael James, Paul Pfeffer, Milica Vukmanovic‐Stejic, Arne N. Akbar, Emma S. Chambers

This study shows that older females have more inflammatory monocytes, which is reversed by Hormone Replacement Therapy.

Aging Cell · Oct 9, 2025Peer-reviewedImmunology

Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods

Wei‐Yu Lin, Melissa Kartawinata, Bethany R. Jebson, Restuadi Restuadi, Hannah Peckham, Anna Radziszewska, Claire T. Deakin, Coziana Ciurtin, Lucy R. Wedderburn, Chris Wallace

This paper compares methods for imputing cell-type specific expression from mixed RNA-seq data, finding that machine learning methods like LASSO and ridge outperform domain-specific methods in recovering differential gene expression.

PLoS Computational Biology · Mar 7, 2025Peer-reviewedBioinformatics

Oestrogen influences B cell class-switching in individuals with an XX sex chromosome complement

Hannah Peckham, Anna Radziszewska, Justyna Sikora, Nina M. de Gruijter, Restuadi Restuadi, Melissa Kartawinata, Lucia Martin‐Gutierrez, George Robinson, Claire T. Deakin, Lucy R. Wedderburn, Elizabeth C. Jury, Gary E Butler, Emma S. Chambers, Elizabeth C. Rosser, Coziana Ciurtin

The paper shows oestrogen affects B cell class-switching only in individuals with an XX chromosomal background.

The Journal of Experimental Medicine · Jan 18, 2025Peer-reviewedImmunology