Restuadi Restuadi

The paper uses multimodal imaging to show that lysosomes act as a reservoir for PARP inhibitors, leading to heterogeneous drug distribution and response in ovarian cancer.

This paper compares methods for imputing cell-type specific expression from mixed RNA-seq data, finding that machine learning methods like LASSO and ridge outperform domain-specific methods in recovering differential gene expression.

The paper shows oestrogen affects B cell class-switching only in individuals with an XX chromosomal background.

The paper compares ten polygenic score methods for psychiatric disorders across multiple cohorts, finding that some methods significantly improve prediction statistics over the baseline PC+T method.